Periconceptional environment and the developmental origins of disease
نویسندگان
چکیده
منابع مشابه
Developmental origins of adult health and disease: the role of periconceptional and foetal nutrition.
The 'developmental origins of adult health and disease' hypothesis stated that environmental factors, particularly maternal undernutrition, act in early life to programme the risks for adverse health outcomes, such as cardiovascular disease, obesity and the metabolic syndrome in adult life. Early physiological tradeoffs, including activation of the foetal hypothalamo-pituitary-adrenal (HPA) axi...
متن کاملDevelopmental origins of adult disease.
Variation in the quality or quantity of nutrients consumed during pregnancy can exert permanent and powerful effects upon the developing fetus. This programming of fetal development is emerging as a new risk factor for non-communicable diseases of adulthood, including coronary heart disease and the metabolic syndrome. Epidemiological studies show that indicators of nutritional deficit in pregna...
متن کاملDevelopmental Origins of Cardiovascular Disease
ardiovascular risk factors are identifiable in childhood and are predictive of adulthood risk for coronary artery disease.1 Autopsy studies of youths have established a strong association between cardiovascular risk factors and early stages of coronary atherosclerosis.2 Longitudinal observation studies have shown that coronary heart disease (CHD) risk factors measured in adolescence predict mar...
متن کاملDevelopmental origins of adult health and disease.
BRAIN SPARING A human baby receiving an inadequate supply of nutrients or oxygen may protect its brain. One way in which it does this is by diverting more blood to the brain at the expense of the blood supply to the trunk. The growth of organs such as the liver is therefore ‘‘traded off’’ to protect growth of the brain. Brain sparing may also be effected through metabolic processes such as insu...
متن کاملDevelopmental origins of health and disease (DOHaD).
OBJECTIVE To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. SOURCES A non-systematic review of the biomedical literature intended to identify historical and current references related to the subject under disc...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2019
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-18-0676